Therapeutic Effects of Serelaxin in Acute Heart Failure
نویسندگان
چکیده
منابع مشابه
Therapeutic effects of serelaxin in acute heart failure.
Over the past few decades, research on the peptide hormone, relaxin, has significantly improved our understanding of its biological actions under physiological and diseased conditions. This has facilitated the conducting of clinical trials to explore the use of serelaxin (human recombinant relaxin). Acute heart failure (AHF) is a very difficult to treat clinical entity, with limited success so ...
متن کاملSerelaxin, a 'breakthrough' investigational intravenous agent for acute heart failure.
Recombinant relaxin (serelaxin), a breakthrough therapy for acute heart failure.
متن کاملEffects of serelaxin in subgroups of patients with acute heart failure: results from RELAX-AHF
AIM Patients hospitalized for acute heart failure (AHF) differ with respect of many clinical characteristics which may influence their prognosis and response to treatment. We have assessed possible differences in the effects of serelaxin on dyspnoea relief, 60 Day outcomes and 180 Day mortality across patient subgroups in the RELAX-AHF trial. METHODS AND RESULTS Subgroups were based on pre-sp...
متن کاملSerelaxin: insights into its haemodynamic, biochemical, and clinical effects in acute heart failure.
Adrian V. Hernandez, MD, PhD, FACC Postgraduate School, Universidad Peruana de Ciencias Aplicadas (UPC), Lima 27, Peru; and Health Outcomes and Clinical Epidemiology Section, Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland,OH 44195, USA. Tel: +51-954157044; email: [email protected] Conflicts of interest: I declare I have no conflict...
متن کاملA randomized, double-blind, placebo-controlled, multicentre study to assess haemodynamic effects of serelaxin in patients with acute heart failure
AIMS The aim of this study was to evaluate the haemodynamic effects of serelaxin (30 µg/kg/day 20-h infusion and 4-h post-infusion period) in patients with acute heart failure (AHF). METHODS AND RESULTS This double-blind, multicentre study randomized 71 AHF patients with pulmonary capillary wedge pressure (PCWP) ≥ 18 mmHg, systolic blood pressure (BP) ≥ 115 mmHg, and estimated glomerular filt...
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ژورنال
عنوان ژورنال: Circulation Journal
سال: 2014
ISSN: 1346-9843,1347-4820
DOI: 10.1253/circj.cj-14-0014